A big effect on small things

BYOTROL PLC AGREEMENT WITH SYNERGY HEALTHCARE PLC

The Directors of Byotrol plc (the "Company") are pleased to announce that the Company has entered into an agreement with Synergy Healthcare plc ("Synergy") which will see Byotrol's anti-microbial technology deployed into the NHS and independent healthcare sector in the UK and the rest of the world.

Synergy Healthcare plc is a leading provider of outsourced medical services to the UK and the Netherlands, with an annualised turnover of over £130million and has over 2500 employees. Synergy has been providing sterile services in the UK since 1996 and is the UK's largest provider of decontamination and sterile services for surgical instruments. The Company operates fifteen facilities and processing approximately 40 million instruments per annum.

The contract gives Synergy exclusive sales and distribution rights to Byotrol's technology in the healthcare market. In addition Synergy will market, sell and distribute Byotrol's Assure product range to the NHS and Byotrol's existing healthcare customers. In the UK, Synergy will assume responsibility for supplying products containing Byotrol to Byotrol's existing healthcare users, Sun Choice Europe Limited and DBM Holdings Ltd.

The agreement will give Synergy the use of Byotrol technology in significant healthcare markets for licences, fees and options totalling £2.3 million together with an advance royalty payment of £400,000,

The agreement commences immediately with the UK market and incorporates options that will grant similar rights to Synergy for both USA, Europe and the rest of the world and these are exercisable between February 2007 and February 2008.

In addition to fees and royalties, Synergy will be purchasing Byotrol concentrates for use in manufacture of anti-microbial products.

The agreement with Synergy demonstrates Byotrol's strategy to deploy its technology in partnership with leading businesses in its chosen markets.

According to Stephen Falder, Deputy Chairman of Byotrol plc:

"This agreement will see the rapid commercialisation of Byotrol technology in the healthcare market and demonstrates our ability to licence the Company's technology to a major organisation allowing us to gain a significant and rapid penetration into one of our chosen key markets.

We continue to progress discussions with several major multinationals regarding an increasing number of opportunities that have been recently identified in the Company's other target markets of Food Processing and Industrial & Technical."

Dr Richard Steeves, Chief Executive of Synergy Healthcare, commented :

"The acquisition of the worldwide rights for Byotrol is a major strategic step forward for Synergy. Byotrol is an ideal fit for Synergy and, coupled with AirCleanse will greatly enhance our product offering in the atmospheric decontamination market. This is an area of critical concern to the healthcare market worldwide in order to counteract the ever-increasing threat of hospital acquired infections.

BYOTROL SECURES MAJOR CONTRACT WITH IRISH HEALTHCARE DISTRIBUTOR

Byotrol, the AIM listed anti-microbial technology company has secured a major contract to supply its technology to Irish based healthcare company Audit Diagnostics which will see Byotrol products used in hospital and medical laboratories worldwide.

Audit Diagnostics is a leading independent supplier of diagnostic products and equipment to hospital and medical laboratories on a global basis.

The contract will see an initial order of £60,000 for Byotrol's technology which is being incorporated into a range of anti-bacterial wipes, sprays and mousses. These will be distributed to hospital and medical facilities worldwide under Audit Diagnostics Sterl STAT brand. The product range will be co-branded with Byotrol positioned as an ingredient brand in line with the company's corporate brand development strategy.

The deal represents a significant milestone for Byotrol because hospital laboratories are among the most demanding environments from an infection control perspective with much of the knowledge and expertise on the subject concentrated within this area of a hospital or medical establishment. The deal also means Byotrol's technology will be deployed within hospitals on a global basis.

The company is confident that this is the first in a series of potential future orders from Audit Diagnostics and Byotrol's technology offers a number of benefits over existing infection control methodologies.

Byotrol's products have been proven through a programme of independent testing to be effective for up to seven days after application and work against a wide range of micro-organisms including E. coli, Legionella and Listeria, as well as MRSA.

The products are not toxic to humans and because of how the technology works, do not promote resistance in susceptible micro-organisms. The chemicals used in the formulation of Byotrol products are suitable for use on a wide variety of surfaces and materials and do not damage or mark the materials during or after usage. They also present an extremely low toxicity profile to humans compared to other disinfectants in use within healthcare environments.

This news comes on the back of a recent announcement from Byotrol that it is seeking to extend its trial with a major NHS teaching hospital designed to test the efficacy of its products in combating the spread of hospital acquired MRSA. The initial phase of the trial was completed recently with encouraging preliminary results that show a significant reduction in environmental MRSA.

ABYOTROL REACHES OUT TO DR RICKY CHAPMAN

Byotrol plc, the anti-microbial technology company has appointed food industry hygiene specialist, Dr Ricky Chapman as an Outreach Manager responsible for building a crucial link between customers and research teams.

Dr Ricky Chapman brings with him a wealth of experience in the food industry having worked at internationally acclaimed food specialists Ecolab for 18 years. Here he worked in a variety of roles from food hygiene specialist, senior hygiene consultant and business development manager through to technical manager for the UK's food and beverage division.

Dr Ricky Chapman studied for a PhD in Corrosion Chemistry at Nottingham University and lives in Derbyshire with his wife, son and 7 month old cocker spaniel puppy.

Commenting on his new role, Dr Ricky Chapman said: "In addition to working closely with the customer and Byotrol's research and development division, I'm looking forward to using my experience to help identify and assess new markets and applications for Byotrol from conception through to implementation. With my extensive knowledge of the food industry I am confident that I will be able to communicate the benefits of using Byotrol in a succinct manner."

Byotrol has a range of specialist anti-bacterial treatments for the food industry. The range of products marketed under the Microsphere brand name is targeted at the food industry to deliver broadband efficacy against a wide range of organisms including E. coli, Legionella and Listeria, as well as MRSA. This wide ranging performance is underpinned by an extremely low toxicity profile compared to other anti-bacterials on the market and Byotrol's technology continues to act for up to several days after application.

Stephen Falder, Byotrol's Business Development Director adds: "As a company we are offering food manufacturer's a total hygiene control solution that eliminates the need to change products every few months to combat resistance. The fact that our technology combines low toxicity and minimal taint with residual efficacy and broadband effect are a real breakthrough for the food industry."

"We are delighted to welcome Ricky Chapman to the team and are confident that he will be able to demonstrate to our customers how our technology is ideally suited for use right across the food industry supply chain from cleaning raw materials on entry through to production line sanitisation and personal hygiene control. At the other end of the chain our fogging products are suitable for not only cleaning manufacturing plants but even transport and containers."

All Byotrol products are available from Byotrol plc on 0161 277 9518

BYOTROL ERADICATES LISTERIA IN CHEESE FACTORY

For cheese manufacturers, control of Listeria is one of the major challenges facing their industry. One proactive company in Cheshire enlisted the help of anti-microbial technology company Byotrol PLC to eradicate any traces of Listeria and ensure that all cheese leaving their factory is Listeria free.

JS Bailey is a successful family owned business, with 60 employees at their factory, distributing between 100 and 120 tonnes of cheese a week to food service organisations and manufacturing companies across the UK.

With three production sites, often cold in temperature, Listeria is always at the forefront of the company's radar to ensure that contamination does not occur. JS Bailey purchase cheese from across the UK and Europe for grating, re-milling and cutting and as such have a superior vetting process to certify that any contaminated cheeses that arrive at the site are removed immediately.

Having worked with several chemical service providers in the past, Dan Smith, QA Manager explains why he is so happy with both the results and level of service received from Byotrol PLC: "We contacted Byotrol PLC to ascertain how we could eradicate and prevent any trace of Listeria. We were absolutely astounded by the findings and in just under 6 months not only are we continuing to use Byotrol but it has eliminated any trace of infection, which for a cheese processing plant is almost unheard of.

"The fact that we no longer have to use a foaming agent is also an added bonus, as not only does using Byotrol reduce our water usage but as foam is very alkaline any aluminium equipment was corroding far too often. With Byotrol our productivity record has increased dramatically and if I ever need any assistance I know that Byotrol are just at the other end of the phone line which is reassuring to know." Dan Smith added.

JS Bailey's cleaning regime now consists of a thorough deep clean of all their equipment including conveyor belts and production lines using Byotrol's fogging machinery. The misting unit applies the Byotrol technology in a fine aerosol and ensures all surfaces, including hard to reach areas, are cleaned. In addition, a hand held trigger spray and disposable wipes impregnated with Byotrol are used for treatment of all hard surfaces.

Byotrol products have a four stage effect on micro-organisms using changes in surface tension as the basis of their attack.

1. Byotrol's component biocides attack micro-organisms on a surface as soon as the product is applied.
2. Byotrol then conditions the surfaces before additional micro-organisms land, making it more difficult for the micro-organisms to settle on the surface, attach and reproduce.
3. When micro-organisms secrete material in an attempt to form a biofilm, (i.e. attachment properties which enable biofilm production) the secretion compounds - proteins, polysaccharides or oily type materials - are all disrupted by the pervading surface tension regime, making it much more difficult or impossible for the organisms to form a firm attachment to the surface.
4. Finally, the micro-organisms, in their weakened state, succumb to Byotrol's residual, long lasting biocidal action provided by its component biocides. These are not aggressive chemical compounds, but when acting on a micro-organism, they cause the organism's membrane to burst before it has a chance to reproduce.

According to Byotrol's Business Development Director Stephen Falder, "We are absolutely delighted with our findings at JS Bailey. As a company we are offering food manufacturer's a total hygiene control solution that eliminates the need to change products every few months to combat resistance. The fact that our technology combines low toxicity and minimal taint with residual efficacy and broadband effect are a real breakthrough for the food processing industry.

"In the long term, our technology can deliver significant cost savings in the area of hygiene while at the same time improving overall performance and control. At present, the cost of using water in a cleaning process is around £4 per tonne by the time it has been made suitable for return to the environment. Because Byotrol's toxicity is several orders of magnitude lower than most other disinfectants on the market and its components are biodegradable, there is a potential immediate saving to be made over conventional biocides in this area alone.

"Our technology is ideally suited for use right across the supply chain from cleaning raw materials on entry through to production line sanitisation and personal hygiene control and at the other end of the chain our fogging products are suitable for not only cleaning cheese manufacturing plants but even transport and containers," Stephen Falder adds.

The Byotrol technology has been fully tested and certified for use in the food industry by the Campden & Chorleywood Food Research Association.

In addition to combating Listeria, the Byotrol products deliver broadband control of a wide range of micro-organisms including Legionella, E.coli, Salmonella, S aureus and campylo bacter coupled with residual effect which means the product continues to be effective for up to seven days after application. Importantly Byotrol is a technology to which organisms cannot develop resistance and offers a cleaning technology with extremely low levels of toxicity compared to anything else on the market. Having passed CCFRA taint tests makes it ideal for use in the food industry.

As well as eliminating the need to change products every few months to combat development of resistance, the Nanosphere product range for food offers a single methodology for managing all areas of infection control depending on the environment.

For management of high care areas, Byotrol is launching a foaming floor and surface cleaner which produces a visible foam when applied, thus ensuring operatives do not miss any areas when cleaning. The Nanosphere range is completed with a pipeline cleaning fluid.

For personal care, Byotrol PLC recommend their foaming hand mousse, which combines long lasting action with an alcohol free formulation that minimises dry skin and dermatitis that sometimes arises from use of products containing alcohol. It is hoped that this will be introduced to the JS Bailey plant later this year.

BYOTROL SECURES CE MARK FOR DISINFECTANT PRODUCTS

The AIM-quoted biocidal technology company Byotrol plc ("the Company") has won a key authorisation allowing it to sell disinfectant products into the European medical market for the first time.

The Company has been awarded CE Marking status, meaning it can now supply its biocidal products for use in disinfectant sprays, wipes and foams.

The CE Mark, found on product labels throughout Europe, indicates that products comply with the relevant requirements of European health, safety and environmental protection legislation.

Byotrol Deputy Chairman Stephen Falder said: "This represents a major milestone for the Company and allows our technology to be sold into the healthcare industry on a pan European basis. As well as opening up business opportunities in Europe, it also means we can sell to UK based companies with European operations that want to deploy a single hygiene regime across their business."

Byotrol has developed unique, patented technology for killing dangerous microbes such as MRSA, Legionella, Listeria and E.coli, as well as ordinary household germs. Uniquely, it provides continuing protection once applied and does not harm organisms larger than microbes.

The new approval also allows the use of the CE Mark by third party suppliers using Byotrol as an ingredient brand in their own products - removing the need for separate additional clearance, and further increasing the size of the potential market.

BYOTROL LAUNCHES MRSA BUSTING ANTI MICROBIAL PRODUCT AND DEODORISER FOR CARE HOMES

Byotrol plc, the anti microbial technology company is launching a range of six products specifically designed to combat the spread of MRSA in care homes.

The range offers long lasting sanitisation and deodorisation in a variety of situations. All products offer long lasting protection against a broad spectrum of micro-organisms including E. coli, Legionella and Listeria, as well as MRSA and continue to be effective for up to seven days after application.

The deodorizing products are highly effective at eliminating odours from a wide range of surfaces and furnishings.

The company is launching the products at Europe's leading conference and exhibition for the care home sector, The Healthcare Event 2006 19-22 January at the Gran Melia Don Pepe Resort, Marbella in Spain.

Byotrol has developed a range of three 750ml trigger spray products suitable for cleaning and sanitising kitchens and bathrooms as well as sanitising and deodorising living areas.

In addition, Byotrol has developed a 600ml pump action sanitising hand mousse dispenser and a 50ml personal hand held dispenser suitable for daily use by care home staff.

The sprays and mousses will be supported by a sanitising wipe product, suitable for general use.

The spread of MRSA and other pathogens represents a major risk within the care home environment. Byotrol's products have been proven through a programme of independent testing to be effective for up to seven days after application and work against a wide range of micro-organisms. The products are not toxic to humans and because of how the technology works, do not promote resistance in susceptible micro-organisms. The deodorising products offer similar levels of long term efficacy and the chemicals used in the formulation of Byotrol products are suitable for use on a wide variety of fabrics and materials and do not damage or mark the materials during or after usage.

The deodoriser is highly effective in eliminating urine odours from carpets and fabrics, a key issue for many care home operators.

Byotrol's products utilise a unique patented technology to deliver this range of benefits.

Byotrol products have a four stage effect on micro-organisms using changes in surface tension as the basis of their attack:

1. Byotrol's component biocides attack micro-organisms on a surface as soon as the product is applied.
2. Byotrol then conditions the surfaces, such as walls or tables, before additional micro-organisms land, making it more difficult for the micro-organisms to settle on the surface, attach, and reproduce.
3. When micro-organisms secrete material in an attempt to form a biofilm, (i.e., what is needed for them to stick to the surface) the secretion compounds - proteins, polysaccharides, or oily type materials - are all disrupted by the pervading surface tension regime, making it much more difficult or impossible for the organisms to form a firm attachment to the surface.
4. Finally, the micro-organisms, in their weakened state, succumb to Byotrol's residual, long-lasting biocidal action provided by its component biocides. These are not aggressive chemical compounds, but when acting on a micro- organism, they cause the organism's membrane to burst before it has a chance to reproduce.

It is a combination of these actions that enable Byotrol to combat the spread of MRSA and other organisms by contact and also make it highly effective in preventing odour from urine and other bodily fluids.

Commenting on the launch of the product range to the care home market, Byotrol plc's Healthcare Director Dr Peter Dandalides said, "This product range delivers real and tangible benefits to users within the care home sector and we have developed the range having listened to the their requirements. Combating the spread of antibiotic resistant organisms in an environment where there are many vulnerable people is a key issue for care home operators and the Byotrol product set addresses this issue head on. Critically, the technology is highly effective when applied to a wide range of surfaces and fabrics and it does not damage or stain them.

CHINESE PATENT GRANTED AND CUSTOMER ORDERS SHIPPED

Byotrol plc (the "Company") is pleased to announce that a patent has been granted in China for its unique biocidal technology, its first for this country.

The patent has been granted around six months earlier than the Company had been forecasting and it will enable the Company to pursue a number of global opportunities it is currently working on, with the confidence that its products will enjoy patent protection within China.

The Company currently has a number of other patents pending in the Far East including Singapore and the granting of the Chinese patent follows successful applications in the UK and South Africa which were granted in 2005 and 2004 respectively. There are currently patents pending for the technology in numerous other countries including the USA, Europe, Canada and Australia and the Company expects these to be granted in due course.

The successful patent application follows the recent announcements of EPA approval in the USA and CE Mark approval in Europe and will enable sales of Byotrol technology in China to proceed under patent protection.

The Company is currently engaged in discussions with a number of global companies regarding deployment of Byotrol's technology and is pleased to able to announce it has secured significant contracts in the industrial and food processing sectors. The Directors consider these contracts demonstrate both the efficacy of Byotrol's technology and the ability of the management team to engage with major global organisations.

Becker Industrial Coatings, one of the world's leading industrial coatings manufacturers has launched a range of anti-microbial coatings containing Byotrol under the BeckryShield brand name. The launch follows extensive trials undertaken to test the efficacy of Byotrol's technology and the BeckryShield range offers effective anti-microbial protection for up to 2 years. The Company will receive revenues from the sale of concentrate and a royalty on sales achieved.

The Company has recently shipped its first customer order to Gold Kist, one of America's largest poultry processing companies, which is using Byotrol technology as part of its hygiene regime initially in its South Carolina processing plant.

Commenting on the successes, Byotrol Deputy Chairman Stephen Falder said:

"Securing the patent in China and winning significant contracts are the latest in a series of milestones for the Company. Importantly they are indicative of the consistent progress with product approvals and protection we are making as well as our ability to work successfully with major organisations. Based on work currently being undertaken and progress to date, the board is increasingly optimistic about future prospects for growth in our chosen market sectors.

BYOTROL SECURES EPA APPROVALS TO OPEN UP NORTH AMERICAN MARKETPLACE

Byotrol plc ("the Company"), the AIM-quoted anti-microbial technology business has succeeded in obtaining approvals from the Environment Protection Agency ("EPA") in the United States for its technology to be used as a disinfectant, sanitiser and anti-microbial product.

As part of this process, the EPA has approved the Company's claims that its technology is effective against a range of micro-organisms including Salmonella, Listeria, MRSA, E.coli and Avian Influenza.

The EPA is the legislative body in the USA which is responsible for protecting human health and the environment. It regulates the approval of new technologies and products for use in these areas, and the performance claims that can legally be made on the product labels.

The approvals follow a 7 month review process undertaken by the EPA and allows Byotrol to market disinfectants and sanitisers in the USA in the Company's initially targeted markets in healthcare, food and industrial technology. As set out in the Admission Document at the time of the AIM flotation, the EPA registration represents an important milestone in the Company's commercial strategy.

The approvals allow the Company to market its products in concentrate form as a sanitiser and disinfectant for domestic use and for customers including hospitals and other healthcare institutions, food processing plants and agricultural facilities (including those subject to inspection by the US Department of Agriculture), restaurants, retail operations, hotels, public transport facilities, schools and universities, health clubs and spas.

The Company has identified significant demand for its products in these areas based on discussions with a number of potential customers who have, until now, been unable to trial or acquire Byotrol's products without the EPA approvals that have now been obtained.

This latest clearance for Byotrol's technology comes days after the Company was awarded CE Mark status for its products which allows it to market its technology to the medical sector on a pan European basis.

Byotrol's Deputy Chairman Stephen Falder commented: "The EPA acceptance of our anti-microbial claims is a very important springboard for key market sectors in the USA. We had originally anticipated that, at this stage, we would receive EPA acceptance for 5 to 7 market-specific claims but I am delighted to say that we have been able to obtain in excess of 20 approvals. Each approval allows us to sell our product in concentrate form to customers in a particular category or market sector. This is considerably ahead of our plan and a significant step forward for the Company following the detailed and complex work of the registration process."

According to the Global Biocides Report, the worldwide biocide market was valued in excess of $5.9 billion in 2005, with the USA the largest user of biocides, and is currently growing at around 4% per annum.

According to David McRobbie, Chief Executive Officer of Byotrol plc, "EPA approval is one of the most significant milestones in the Company's development to date. The approval, which was achieved on time and within budget, opens up the vast United States market for our technology and allows us to sell our products into a broader spectrum of sectors than we had originally anticipated. This builds on our progress in the UK and Europe where we have started to sell our products in a broad range of markets, from care homes and medical laboratories through to food processing and industrial coatings

RHYS INTERNATIONAL TURN TO BYOTROL FOR MICROBIAL CONTROL SOLUTION

Anti-microbial technology company Byotrol plc has given Rhys International authorisation to promote, sell and distribute their new innovative range of Nanosphere and Intersphere biocide products.

Byotrol's Nanosphere range is designed specifically for the Food and Beverage industries and comprises a full portfolio of products to tackle all the hygiene issues involved in today's complex commercial food environments, such as preventing and combating pathogens including listeria and salmonella.

Byotrol's Intersphere range is the first product to effectively and permanently control micro-organisms which develop into algae and other similar fungal species. Byotrol's Intersphere range is split into three clear areas namely, "Clearway" which is specifically developed for reducing microbial biofilm on items such as road signs, street furniture, bus shelters and solar panels; "Inhibitor" for use in high exposure areas around coastal and inland waterways such as slipways, pontoons and decking and "Sanitizer" which is ideal for areas where mico-organisms, including moulds cause a contaminating problem - ideally used for door handles, WC handles and washing machines.

Byotrol products have a four stage effect on micro-organisms using changes in surface tension as the basis of their attack.

1. Byotrol's component biocides attack micro-organisms on a surface as soon as the product is applied.
2. Byotrol then conditions the surfaces before additional micro-organisms land, making it more difficult for the micro-organisms to settle on the surface, attach and reproduce.
3. When micro-organisms secrete material in an attempt to form a biofilm, (i.e. attachment properties which enable biofilm production) the secretion compounds - proteins, polysaccharides or oily type materials - are all disrupted by the pervading surface tension regime, making it much more difficult or impossible for the organisms to form a firm attachment to the surface.
4. Finally, the micro-organisms, in their weakened state, succumb to Byotrol's residual, long lasting biocidal action provided by its component biocides. These are not aggressive chemical compounds, but when acting on a micro-organism, they cause the organism's membrane to burst before it has a chance to reproduce.

Byotrol's products have been proven through a programme of independent testing to be effective for up to seven days after application and work against a wide range of micro-organisms. The products are not toxic to humans, animals or plants and significantly the technology does not promote resistance in susceptible micro-organisms.

Barry Coyle of Rhys International comments: "During the past two years Rhys International has been augmenting the existing product range with relative anti-microbial products. We have been involved in a number of microbial technologies, designed and manufactured to address the growing menace of micro-organisms in our environment. We fully understand the need to address the problem and are well situated to offer a solution that works. To this end we are very pleased to be distributing Byotrol's innovative Nanosphere and Intersphere biocide products. With Byotrol's long lasting residual properties and vast number of applications, microbial contamination can now be treated and controlled effectively."

Byotrol's Sales Manager, Gary Hilton adds: "We look forward to a successful relationship with Rhys International and are delighted to have their support for our Nanosphere and Intersphere range. This association will provide us with the opportunity to distribute the Nanosphere and Intersphere range to researchers and technicians across the UK and Europe - delivering real and tangible benefits."

Rhys International is a leading provider of scientific supplies to the UK and Europe. From its warehouse and distribution centre in Bolton, the company provides researchers, technicians and alike with all the necessary tools to carry out their work effectively. As a registered waste carrier with the Environment Agency, Rhys International can also offer customers professional advice & turnkey solutions to hazardous waste situations, such as decontamination and environmental controls.

For Byotrol products please contact Rhys International on 01204 848 430 and for further information please contact Byotrol Technology Ltd on 0161 277 9518

BYOTROL plc - NHS PRODUCT LAUNCH

The Directors of Byotrol plc (the "Company") are pleased to be able to report that the Company's strategic healthcare partner Synergy Healthcare plc has announced the launch of a range of anti-microbial products containing Byotrol technology.

The products have been developed for sale to the NHS primary and acute care sectors and these will be marketed under the assure plus brand name.

A range of products for use in care homes will be marketed under the assure brand name.

Byotrol Deputy Chairman Stephen Falder said, "We are delighted that our healthcare partner has launched a comprehensive product range into the marketplace and this coupled with the work we have undertaken to prove the efficacy of the Byotrol technology will act as key drivers for sales in the months ahead."